Tadalafil

CMOAPI nwere akụrụngwa akụrụngwa nke Tadalafil, ma nwee njikwa njikwa dị mma ..Agabiga GMP na asambodo DMF.

Egosi 3 pụta

Kedu ihe bụ Tadalafil

Tadalafil bụ ọgwụ ọgwụ eji agwọ ọrịa na-agwọ ọrịa erectile (ED) yana mgbaàmà nke ịbawanye prostate na ụmụ nwoke. A na-egosikwa ya ịgwọ ọbara mgbali elu (PAH).
Tadalafil (Nọmba CAS: 171596-29-5) dị n'ụdị mbadamba ọnụ ma ọ bụ tadalafil uzuzu ma na-ere ya n'okpuru aha Cialis (maka nrụrụ erectile ma ọ bụ nnukwu prostate) ma ọ bụ Adcirca (maka ọbara mgbali elu). Tadalafil dịkwa na ụdị ọnụọgụ ya nke nwere ike ọ gaghị enwe ike niile dị ka nhazi mbụ


Kedu ka tadalafil si arụ ọrụ?

Tadalafil bụ otu n'ime ndị na-emechi ụdị 5 (PDE5) nke phosphodiesterase. Mgbe otu ọgwụ ndị a na-egbochi PDE5 ha na-eme ka ọrụ erectile dịkwuo elu.
N'oge agụụ mmekọahụ, ọkpụkpụ na-eme mgbe enwere ọbara zuru oke na akwara penile nke na-ebute akwara izu ike na akwara dị nro nke corpus cavernosum. Nzaghachi a na-edozi site na mmepụta nke nitric oxide (NO) na sel endothelial na akwara akwara. Ntọhapụ nke NO na-eme ka njikọ nke cyclic guanosine monophosphate (nke a na-akpọkarị GMP ma ọ bụ cGMP cyclic) dị na sel ahụ dị mma. GMP ahụ na-enyere aka mee ka uru ahụ dị nro na-eme ka ọbara na-asọba na corpus cavernosum.
Tadalafil na-egbochi ụdị 5 (PDE5) nke phosphodiesterase site na ịba ụba nke cGMP. Ọ dị mma ịkọba na mmadụ ga-enwerịrị mkpali mmekọahụ iji malite mbupute nke nitric oxide. Nke a bụ n'ihi na nsogbu Tadalafil agaghị eme na-enweghị mkpali mmekọahụ.
Tadalafil nwere ike belata mgbaàmà nke gland prostate gbasaa gụnyere urination ọsọ ọsọ / ugboro ugboro, nsogbu na nsị, na urinary incontinence. Ọ na-eme nke a site na izu ike ahụ na prostate na eriri afo.
Na ọbara mgbali elu, tadalafil na-enyere aka mee ka akwara ọbara dị n'ime obi. Nke a na - enyere aka ịbawanye n'ọbara na ngụgụ ma na - ebelata ọrụ obi.


Intermediates nke Tadalafil

N'ime usoro ịmepụta tadalafil (CAS 151596-29-5), a na-ahazi ụfọdụ ndị nnọchi anya. Companiesfọdụ ụlọ ọrụ ga-eji tadalafil intermediates mepụta tadalafil.

Cas 171596-29-5

Tadalafil (CAS 171596-29-5) bụ ọgwụ ndenye ọgwụ dị ike ma dị irè maka ịgwọ ọrịa na-erectile na ịba ụba nke prostatic na ụmụ nwoke yana ọbara mgbali elu.

Cas 171489-59-1

Cas 171489-59-1 akpọkwara dị ka Chloropretadalafil bụ etiti dị na mmepụta nke Tadalafil eji mee ihe n'ịgwọ ọrịa nrụrụ erectile. CAS 171489-59-1 nwere usoro ihe omimi C22H19ClN2O5 nwere ihe omimi nke 426.85 g / mol. A na-enweta ya n'ụdị nke siri ike na-acha ọcha.

Cas 171752-68-4

CAS 171752-68-4 nke ihe omuma ya bu C20H18N2O4.HCl na ihe omimi nke 386.83 g / mol bu kwa onye ozo tadalafil.
E nwere ọtụtụ ndị na-eweta tadalafil intermediates ndị na-enye tadalafil intermediates maka ire ere na asọmpi ọnụahịa. Otú ọ dị, mgbe ị tụlere tadalafil zụta ya n'aka ụlọ ọrụ ndị tụkwasịrị obi iji hụ na ogo adịghị oke.
CMOAPI bụ otu n'ime ndị na-eweta ngwaahịa tadalafil nke na-ekwe nkwa ịdị mma na ọnụahịa nke ngwaahịa ha.


Onye na otu esi eji tadalafil

Tadalafil uzuzu nwere ike ịgwọ ndị na-esonụ n'ime ụmụ nwoke?

Erectile na-arụ ọrụ

Erectile dysfunction (ED) a na-akpọkwa enweghi ike bụ ọnọdụ na ụmụ nwoke na ha enweghị ike ịnweta ma ọ bụ debe ụlọ maka oge zuru ezu iji nwee mmekọahụ. Ọ na-edugakarị n'inwe mmasị na mmekọahụ ma ọ nwere ike ibute nsogbu ndị ọzọ dịka ịla n'iyi ma ọ bụ igbu oge na mgbe ụfọdụ enweghi ike iru orgasm.
ED nwere ike ibute ọtụtụ ihe kpatara ya ma ọnọdụ anụ ahụ na nke mmetụta uche dịka ọrịa ụfọdụ dị ka ọrịa shuga, ọrịa obi, na ọbara mgbali elu, afọ, nchekasị, ma ọ bụ ọbụlagodi mmekọrịta.
Tadalafil na-enyere aka ịgwọ ED site na ịbawanye ọbara na amụ. Nke a na - enyere aka iru ma debe ụlọ. Otú ọ dị, tadalafil na-enyere aka na erection mgbe mmadụ na-akpali agụụ mmekọahụ.

Benign prostatic hyperplasia (BPH)

A na-akpọkwa ya dị ka mgbatị nke prostate, BPH bụ ọnọdụ nkịtị a na-ahụkarị na ụmụ nwoke mgbe ha mere agadi. Agbanyeghị, ọtụtụ ihe ndị ọzọ nwere ike ibute ọrịa prostate gbasaa gụnyere ọrịa shuga na ọrịa obi, ibi ndụ, yana oke ibu yana akụkọ ntolite ezinụlọ nke BPH. Mgbe prostate na-ebuwanye ibu, ọ nwere ike ibute ọnọdụ urinary.
Mgbaàmà ndị metụtara gland prostate gbasaa bụ, na-agba ọsọ ngwa ngwa na urinate, na-enwe nsogbu ịmalite urinate, mmiri mmamịrị na-esighi ike, ma ọ bụ enweghị ike iwepụ eriri afọ ahụ kpamkpam. Ihe ịrịba ama ndị ọzọ nke BPH nwere ike ịgụnye ọrịa urinary tract (UTI), enweghị ike ịmị mamịrị, ma ọ bụ ọbara n'ime mmamịrị ahụ.
Tadalafil uzuzu ma ọ bụ mbadamba na-enyere aka ime ka akwara dị na prostate na eriri afo. Nke a na-enyere aka belata mgbaàmà nke BPH.

Ọbara akpa ume ọbara mgbali elu (PAH)

PAH bụ ọnọdụ ọbara mgbali elu dị na akwara ọbara na-enye ọbara na ngụgụ. Ọ dị iche na ọbara mgbali elu nkịtị. Ọ na - eme mgbe akwara akwara si n’obi rue ngụgụ dị warara ma ọ bụ egbochie ya.
Ihe mgbaàmà kachasị ama gụnyere mgbu obi, ike ọgwụgwụ, ma ọ bụ ọzịza na ụkwụ na nkwonkwo ụkwụ gị.
Tadalafil nwere ike inye aka belata mgbaàmà nke PAH site na ime ka arịa ọbara dị na ngụgụ ume nke na-eme ka mmụba ọbara na-aga n'ihu.

Kedu esi eji tadalafil?

Agedị tadalafil dabere na afọ gị, iji ya eme ihe, yana nsogbu ọ bụla gbasara ahụike.
A naghị atụ aro iji Tadalafil maka ụmụaka n'okpuru afọ 18 ka ndị agadi gafere afọ 65 kwesịrị ịkpachara anya ebe ọ bụ na ahụ ha na-ewe ogologo oge ịmị ọgwụ ndị a.
Enwere ụkpụrụ nduzi doro anya banyere otu esi eji ntụ ntụ tadalafil mana ụdị kachasịkarị bụ mbadamba tadalafil n'okpuru aha dị iche iche.
Ọ bụ ihe amamihe dị na ya iji tadalafil otu ugboro kwa ụbọchị ma were ya n'otu oge kwa ụbọchị iji nweta uru tadalafil.
A kọwapụtara usoro ọgwụgwọ tadalafil maka ojiji dị iche iche;
Maka nrụrụ erectile, a na-ewere ọgwụ nke 2.5-5 mg kwa ụbọchị ma ọ bụ 10 mg mgbe a na-ewere ya otu ugboro dịka mkpa ọ bụla.
Maka ọrịa hyperplasia prostatic na-adịghị mma, a na-atụ aro ọgwụ nke 5 mg kwa ụbọchị. E kwesịrị ị Tụ Tadalafil otu ugboro kwa ụbọchị.
Mgbe ị na-emeso ọnọdụ abụọ ahụ (nrụrụ erectile ma gbasaa prostate) usoro ọgwụgwọ 5 mg kwa ụbọchị kwesịrị ekwesị.
Site na ọbara mgbali elu ọbara, a na-atụ aro usoro ọgwụ tadalafil nke 40 mg kwa ụbọchị.
Dị ka ọgwụ ndị ọzọ, ihe na-arụ ọrụ maka otu nwere ike ọgaghị eme otu ihe ahụ onye ọzọ. Uzo ozo nke Tadalafil di. Otú ọ dị, ihe kachasị mma ị ga-eme bụ ịgwa dọkịta gị gbasara ndị dịnụ tadalafil ndị ọzọ ma hụ nke kachasị gị mma. Enwere ike ịgwa gị ka ị were ndị ọzọ tadalafil ma ọ bụrụ na ị na-arịa tadalafil ma ọ bụ n'ihi ihe ndị ọzọ.
Ọ bụ ọrụ gị ịkọba ihe na-arụ ọrụ nke ọma maka gị mgbe ị na-achịkwa tadalafil bụ nhọrọ ma ọ bụ mmetụta nke tadalafil na-akwụ ụgwọ uru tadalafil.


Kedu ọdịiche dị n'etiti Tadalafil na ọgwụ ndị ọzọ maka nrụrụ erectile

Cialis (Tadalafil)

Cialis bụ ọgwụ ederede edere na klaasị ọgwụ ndị a na-akpọ Phosphodiesterase-5 Enzyme Inhibitors. A na-eji ya agwọ ihe mgbaàmà nke nrụrụ erectile. Enwere ike iji ya naanị ma ọ bụ tinye ya na ọgwụ ndị ọzọ.

Dapoxetine Hydrochloride

A na-ekewa Dapoxetine hydrochloride dị ka onye na-eme ngwa ngwa serotonin reuptake inhibitors (SSRIs).
Dapoxetine hydrochloride bụ ọgwụ edebanyere aha iji na-emeso ejaculation akaghi aka. Ejaculation oge na-adịghị anya bụ ọnọdụ zuru oke na ụmụ nwoke na-agụnye enweghị ike igbu oge. Nke a bụ otu ihe mgbaàmà nke nrụrụ erectile na ụmụ nwoke.
Ọ bụ ezie na eji tadalafil na dapoxetine hydrochloride na-agwọ ihe mgbaàmà nke nrụrụ erectile, otu tadalafil bụ onye na-eme ihe na phosphodiesterase ebe onye nke ọzọ, dapoxetine, bụ onye na-emechi ihe nchịkwa serotonin.

Vardenafil Hydrochloride

Vardenafil bụ ọgwụ na otu ọgwụ ọgwụ akpọrọ phosphodiesterase (PDE) inhibitors. A na-eji ya agwọ ọrịa nwoke erectile. Mgbe nwoke ahụ na-akpali agụụ mmekọahụ, vardenafil na-eme ka ọbara na-asọba na amụ na-eme ka o doo anya na ị ga-enwe ụlọ.
Vardenafil rere n'okpuru aha aha Levitra bụ nhọrọ dị oke mma karịa sildenafil na tadalafil (Cialis) na PDE5. Nke a pụtara nanị na achọrọ obere vardenafil na obere mmetụta dị obere.
Ihe ọzọ dị ịrịba ama bụ na ọkara ndụ ebe vardenafil (Levitra) nwere ọkara ndụ nke 4-6 awa mgbe tadalafil (Cialis) nwere ọkara ndụ nke 17.5 awa. Nke a pụtara na Tadalafil (Cialis) na-eme ogologo oge karịa vardenafil.

Avanafil

Avanafil bụ ọgwụ dị na otu ndị na-emechi phosphodiesterase. A na-ejikwa ya iji gwọọ nrụrụ erectile site na imeziwanye ọbara na mpaghara penile.
Ọ bụ ezie na avanafil na tadalafil bụ ndị na-emechi phosphodiesterase, avanafil bụ nke kachasị ọhụrụ ma nwee obere ndụ nke ihe dịka 5 awa karịa tadalafil nke nwere ọkara ndụ nke 17.5 awa.
Na mmechi, tadalafil dị mma karịa ogologo ndụ ya. Onye nwere ike ị theụ ọgwụ ahụ na mmetụta ole na ole nwere ike.


Tadalafil mmetụta na uru

Tadalafil uru

Ọtụtụ ndị na-atụle iji tadalafil uzuzu zụta ya n'ihi uru nke tadalafil bụ isi;

Na-emeso nrụrụ erectile

Penile erection bụ usoro dị mkpa maka inwe mmekọahụ. Erectile adịghị arụ ọrụ na-eme mgbe mmadụ enweghị ike ịnweta ma jigide ya. Nke a na - ebute ọtụtụ nsogbu dịka nsogbu, enweghị nsọpụrụ, na ọbụnakwa nsogbu mmekọrịta.
A na-enweta nrụpụta mgbe enwere ọbara zuru oke na amụ. Tadalafil na-enyere aka belata mgbaàmà nke nrụrụ erectile site na ịbawanye ọbara na amụ.

Na-emeso mgbaàmà nke hyperplasia prostatic benign

A na-akpọkwa hyperplasia na-ahụ maka ọrịa prostate na-ebuwanye ibu. Nke a bụ ọnọdụ na-adịkarị na ebumpụta ụwa. Mgbe prostate gland na-ebuwanye ibu, ọ na-apịa mamịrị. Fọdụ n'ime ihe mgbaàmà metụtara na ịbawanye prostate bụ; urination ngwa ngwa na oge, o siri ike ịmalite urination, urination na-egbu mgbu n'etiti ndị ọzọ.
Tadalafil na-erite uru maka ụmụ nwoke na-arịa hyperplasia prostatic benign site na ịkwụsị mgbaàmà ndị a. Tadalafil uzuzu na-enyere aka mee ka gland na-eme ka prostate gland na eriri afọ ya na-ebelata mgbaàmà ndị metụtara eriri afọ na urethra.

Nwere ike ịgwọ ọrịa na erectile na hyperplasia prostatic

Tadalafil nwekwara ike inyere ụmụ nwoke aka na-arịa ọrịa na-erectile ma gbasaa gland prostate n'otu oge.
Mgbe ị na-eji tadalafil mee ihe ziri ezi ma dị ka akwadoro ị ga-erite uru ndị ahụ. Ebe ọ bụ na m na-eme ka ọbara na-asọba na mpaghara penile yana na mpaghara ndị ọzọ, ọ bụ ụzọ dị mma iji merie ọnọdụ ndị a.

A pụkwara iji ya na ịgwọ mgbaàmà ọbara mgbali elu ọbara

Ọbara mgbali elu (PAH) pụtara n'ụzọ pụtara na enwere ọbara mgbali elu dị na akwara akwara na-ewe ọbara site na obi gaa na ngụgụ. Otú ọ dị, ọ dị iche na mgbali elu ọbara mgbe niile.
PAH na-adị mgbe akwara ndị na-enye ọbara na ngụgụ na-adị warara ma ọ bụ na-egbochi obi na-amanye ịmịnye ọbara n'ọtụtụ dị elu. Ọsọ a ma na-amanye obi na-ebute oke nrụgide na akwara.
Tadalafil uzuzu na-eju anya site n'ime ka arịa ọbara dị jụụ. Ntụrụndụ a na-enye ohere maka ịmị nwayọọ nke ọbara wee si otú a mee ka ọnụọgụ na-erugharị. Nke a na - enyere obi aka ịna - amịpụta ọbara dị nro ka ọ na - ebelata nrụgide nke ga - agbakọ

Emeziwanye ikike ịmega ahụ

N'oge mmega ahụ ọbara na-erugharị dị mkpa iji nye mmadụ ohere ịnweta oxygen zuru oke yana iwepụta ike zuru ezu chọrọ.
Tadalafil nwere ike ịkwalite mmega ahụ gị site na ime ka arịa ọbara gị dị jụụ na ịbawanye ọbara.

Mmetụta Tadalafil

Mmetụta uto tadalafil kachasị dị na ya gụnyere;

  • Isi ọwụwa,
  • Ọgbụgbọ,
  • iwe (ọkụ, acha ọbara ọbara, ma ọ bụ mmetụta na-agwụ ike),
  • afọ iwe,
  • mkpọchi ma ọ bụ imi na-agba agba, na
  • mgbu mgbu, azụ mgbu, na mgbu na aka gị ma ọ bụ ụkwụ.

Tadalafil nwekwara ike ibute nsonaazụ ka njọ. A dụrụ gị ọdụ ka ị chọọ enyemaka ahụike ma ọ bụrụ na ịnwee nke ọ bụla n'ime ihe ndị na-eso tadalafil;

  • ụfọdụ mgbaàmà obi mgbawa nke gụnyere mgbu obi, mgbu na-agbasa na agba ma ọ bụ ubu, ọgbụgbọ, na ọsụsọ.
  • ọhụụ na-agbanwe gụnyere nhụhụhụhụhụhụhụhụhụ ọhụụ ma ọ bụ ọhụụ mberede.
  • iwe (ọkụ, acha ọbara ọbara, ma ọ bụ mmetụta na-agwụ ike),
  • Nrụrụ ntị na
  • na-akụ na ntị gị na ịnụ ntị
  • Ererụ ụlọ nke na-egbu mgbu ma ọ bụ karịa ogologo oge 4 ka nke a nwere ike imebi amụ gị.
  • vomiting
  • Obi mgbaghara
  • Da mba, dizziness na,
  • Ike ọgwụgwụ pụrụ iche.

Mmekọrịta ọgwụ nke Tadalafil

Ọtụtụ mkparịta ụka tadalafil na ọgwụ ndị ọzọ ekwupụtala. Mkparịta ụka ọgwụ na-agbanwekarị ọrụ nke ọgwụ ahụ ma nwee ike igbochi ọgwụ ndị ahụ ịrụ ọrụ nke ọma.
Ya mere, a na-adụ gị ọdụ ka ị kwurịta ọgwụ gị tupu ị jiri tadalafil. Tadafọdụ mkparịta ụka tadalafil nwere ike ịdị nro na nsogbu ndị ọzọ.
N'okpuru ebe a bụ mmekọrịta nke tadalafil;

Nitrates

A na-akpọkwa ha ọgwụ Anguina. Mgbe ejiri nitrates na tadalafil, ọ nwere ike ime ka ọbara mgbali elu na-adaba na ọkwa dị ala. Ejikọtara ọnọdụ dị ala nke ọbara mgbali na mgbaàmà ndị dị ka nju anya ma ọ bụ ọbụna ịda mba.
Fọdụ n'ime ọgwụ anguina ndị a gụnyere; butyl nitrite, amyl nitrite, isosorbide dinitrate, nitroglycerin, na isosorbide mononitrate.

Ndị na-egbochi Alpha-blockers

Ihe ndị a bụ ọgwụ eji agwọ ọbara mgbali elu. A na-ejikwa ha ọgwụgwọ prostate. Ma tadalafil na alpha-blockers bụ vasodilators nwere ọbara mgbali na-ebelata mmetụta. Mgbe e jikọtara ya ọnụ, ọ nwere ike ibute ọbara mgbali ike / dị egwu. Nke a na - eme ka mmadụ tụbọọ ma nwekwaa nkụda mmụọ.
Fọdụ ọgwụ ọgwụ alpha-blockers gụnyere; terazosin, tamsulosin, alfuzosin, na prazosin.

Drugsfọdụ ọgwụ nje HIV

Ọgwụ ndị a bụ ndị na-eme ihe na-egbochi proteinase ma ya mere ha nwere ike ime ka ọkwa tadalafil dị n'ọbara bawanye. Nke a na - ebute ọbara mgbali elu. O nwekwara ike ime ka mmadụ ghara ịba uru nke pụtara na ha nwere ụlọ dị ogologo nke na-egbu mgbu.
Fọdụ n'ime ọgwụ ndị a bụ ritonavir na lopinavir.

Ọgwụ nje

A kọọrọ mkparịta ụka Tadalafil na ọgwụ nje. Mgbe ejiri ya na tadalafil mee ihe, ọgwụ nje nwere ike ime ka tadalafil dị n'ọbara nke na-eduga n'ịbelata ọbara mgbali. Ya nwere ike ịkpata dizzness, ịda mba, na ọbụna ụfọdụ ọhụụ ọhụụ. O nwekwara ike ime ka mmadụ ghara ịna-amata onye ọ bụ.
Fọdụ n'ime ọgwụ ndị a bụ erythromycin, telithromycin, na clarithromycin.
Agbanyeghị, ụfọdụ ọgwụ nje nwere ike belata ọkwa nke tadalafil n'ọbara. Mkparịta ụka tadalafil ndị a anaghị arụ ọrụ nke ọma. Ọgwụ ndị a gụnyere; rifampin.

Antifungal ọgwụ

Fọdụ ọgwụ ọgwụ na-egbu egbu gụnyere ketoconazole na itraconazole na-emekọrịta na tadalafil.
Ọgwụ ndị a nwere ike ibuli ọkwa nke tadalafil nke na-eduga na nhụjuanya na nkụda mmụọ nwekwara ike ime.

Ndị ọzọ na-arịa ọbara mgbali elu

A maara Tadalafil na ọgwụ ndị ọzọ na-arịa ọbara mgbali elu na ha nwere mmetụta ọbara na-ebelata ọbara. Mgbe e jikọtara ya ọnụ nwere ike ibute ogo ọbara mgbali elu dị egwu. Nke a na - ebute ihe mgbaàmà metụtara ọbara mgbali elu dị ka ọzịza na nkụda mmụọ.
Ọgwụ ndị ahụ gụnyere riociguat.

Ihe mgbochi

A na-eji ọgwụ ndị a eme ihe iji belata acid afo. Mgbe ejiri ya na tadalafil, ha nwere ike igbochi absorption nke tadalafil n'ime ahụ. Ha gụnyere magnesium hydroxide ma ọ bụ aluminom hydroxide.

Ọgwụ akwụkwụ

A na-akpọkwa ọgwụ ndị a ọgwụ mgbochi. Mgbe ị na-a drugsụ ọgwụ mgbochi na-ejide ọgwụ na tadalafil, ha nwere ike belata ntinye nke tadalafil. Nke a pụtara na tadalafil agaghị arụ ọrụ nke ọma. Ngwá ọgwụ ndị a na-efe efe gụnyere phenytoin, phenobarbital, na carbamazepine.


Ebee ka ịzụta Tadalafil?

Nwere ike ime Tadalafil zụta na ụlọ ahịa dị n'ịntanetị. Ntụ ntụ dị n'ọtụtụ maka ndị na-eme nchọpụta na ndị nyocha. Jide n'aka na ịlele maka ndị na-ebugharị tadalafil uzuzu kwadoro.
Gaa dọkịta gị tupu ị na-ewere tadalafil n'ihi nsonaazụ tadalafil nwere ike yana yana mmekọrịta tadalafil na ọgwụ ndị ọzọ.
Ọ bụrụ na ị na-achọ Tadalafil ma ọ bụ ndị etiti ya, ị kwesịrị ịlele na CMOAPI maka ezigbo ngwaahịa dị mma. Ogige anyị enwetawo mmesi obi ike dị mma.


References
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  3. "Cialis tadalafil PI". Nchịkwa Ngwaahịa ọgwụgwọ. Weghachite 2020-08-19.
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