Cannabidiol (CBD)

Cannabidiol (CBD) ntụ ntụ Ozi ala

aha	Cannabidiol （CBD）
ọdịdị	White ọcha edo edo crystalline ntụ ntụ
Cas	13956-29-1
nnwale	≥99% (HPLC)
Solubility	Soluble na mmanụ, nke nwere ike ịgbakwunye na ethanol na methanol, anaghị agbasa na mmiri
molekụla arọ	314.46
Melt Point	62-63 ° C
molekụla Formula	C21H30O2
Source	Ulo oru hemp
nchekwa temp	Temperaturelọ okpomọkụ, na-akọrọ ma pụọ ​​n'ìhè
ọkwa	Nlekọta ọgwụ

 

Gịnị bụ Cannabidiol (CBD)?

A maara Cannabidiol dị ka CBD nke bụ otu n'ime ogige ọgwụ kemịkal 100 a maara dị ka cannabinoids dị na ahịhịa ma ọ bụ osisi wii wii, Cannabis sativa. Ọ dịpụrụ adịpụ ma sachapụ ya na ahịhịa Cannabis sativa, naanị nwere obere THC. Tetrahydrocannabinol (THC) na cannabidiol (CBD) na-eso ndị na-anabata Cannabinoid na-emekọrịta ahụ dum. E jiri ya tụnyere 9-THC, CBD anaghị egbu egbu n'ihi na ọ naghị egosipụta ọrụ psychoactive. Ọ nwere analgesic, mgbochi mkpali, antineoplastic na chemopreventive eme. N'elu nchịkwa, cannabidiol (CBD) na-arụ ọrụ na-egbochi proliferative, anti-angiogenic na pro-apoptotic site na usoro dị iche iche, nke nwere ike ọ gaghị agụnye akara ngosi site na onye na-anabata ihe na 1 1 (CB2), CB1, ma ọ bụ onye na-anabata vanilloid 1. CBD na-akpali endoplasmic reticulum (ER) nrụgide ma gbochie akara ngosi AKT / mTOR, si otú ahụ na-arụ ọrụ autophagy ma na-akwalite apoptosis. Tụkwasị na nke ahụ, CBD na-eme ka ọgbọ nke ikuku oxygen na-eme ihe (ROS) dịkwuo mma, nke na-eme ka apoptosis dịkwuo mma. Onye ọrụ a na-edozigharị okwu nke 1 (ICAM-1) nke adhesion molekụla adhesion na onye na-egbochi anụ ahụ nke matrix metalloproteinases-1 (TIMP1) ma belata okwu nke mgbochi nke DNA na-ejikọ 1 (ID-2). Nke a na-egbochi cancer cancer invasiveness na metastasis. CBD nwekwara ike ịgbalite onye na-anabata ihe na-agafe agafe nke nwere ụdị vanilloid 2 (TRPV1), nke nwere ike ịbawanye nnabata nke ndị ọrụ cytotoxic dị iche iche na mkpụrụ ndụ kansa. A na-echekwa mmetụta nke analgesic nke CBD site na njikọ nke onye ọrụ a na mmalite nke CB2018. A na-ejikarị Cannabidiol mee ihe maka ọrịa mberede (epilepsy) ma ọ bụ ọrịa dravet na enyemaka nke mgbaàmà nke nhụjuanya neuropathic ma ọ bụ ọnọdụ ndị ọzọ na-egbu mgbu, dị ka ọrịa kansa. FDA kwadoro CBD na XNUMX, ọ bụkwa naanị FDA kwadoro ọgwụgwọ maka ndị ọrịa nwere ọrịa Lennox-Gastaut na ọrịa Dravet.

 

Cannabidiol (CBD) Ime ihe

Achọpụtaghị usoro ọrụ nke CBD na THC ugbu a. Otú ọ dị, a maara na CBD na-eme ihe na Cannabinoid (CB) ndị natara usoro endocannabinoid, nke a na-ahụ n'ọtụtụ akụkụ ahụ, gụnyere akụkụ ahụ na etiti usoro ụjọ, gụnyere ụbụrụ. Usoro endocannabinoid na-achịkwa ọtụtụ nzaghachi nke anụ ahụ gụnyere mgbu, ncheta, agụụ na ọnọdụ. N'ikwu ya n'ụzọ doro anya, a pụrụ ịchọta ndị natara CB1 n'ime ụzọ nhụjuanya nke ụbụrụ na eriri afọ ebe ha nwere ike imetụta ọrịa analgesia na anxiolysis nke CBD, na ndị nabatara CB2 nwere mmetụta na sel ndị na-adịghị ahụkebe, ebe ha nwere ike imetụta usoro mgbochi mgbochi nke CBD. . Cannabidiol (CBD) bụ metabolism na-eme n'ime imeju na eriri afọ. Ise bioavailability na-ese anwụrụ bụ ihe dịka 31%. Ọkara ndụ CBD mgbe oromucosal ịgba dị n'agbata oge 1.4 na 10.9, ụbọchị 2 na 5 mgbe ị oralụ nri na-adịghị ala ala, yana awa 31 mgbe ị smokingụ sịga. CBD ga - enweta oke plasma dị n'etiti 0 na 4 elekere. E gosipụtara CBD ka ọ rụọ ọrụ dị ka onye na-adịghị mma allosteric modulator nke Cannabinoid CB1 onye nnata, onye G-Protein Coupled Receptor (GPCR) kachasị na ahụ. A na-enweta usoro Allosteric nke onye natara site na ngbanwe nke ọrụ nke onye nnata na saịtị dị iche iche site na saịtị agonist ma ọ bụ antagonist. Mmetụta mmetụta na-adịghị mma nke allosteric na-adịghị mma dị ka ọgwụgwọ dị ka ndị agonists kpọmkwem na-ejedebe site na mmetụta psychomimetic ha ebe ndị na-emegide onwe ha na-ejedebe site na mmetụta ịda mba ha.

 

Otu esi eji Cannabidiol (CBD)?

Cannabidiol (CBD) bụ mkpụrụ osisi cannabis nke a na-atụle maka uru ahụike ya. Wayszọ abụọ a na-ahụkarị iji were ya n'ahịa bụ okwu ọnụ na isiokwu dị ka capsules, tinctures, creams, na ndị ọzọ .CBD mmanụ bụ ụdị ngwa ngwa kachasị ewu ewu, ọ bụ ụzọ dị mma iji tinye cannabinoid. S iloda ọtụtụ mmiri nke mmanụ CBD na-arụ ọrụ dị ka ụzọ kachasị mfe na nke kachasị dị mfe iji rie mọdụlụ na ụdị a. Cannabidiol nwere ike ọ bụrụ na ejiri ya n'ọnụ ma ọ bụ fesa ya n'okpuru ire ya n'ụzọ kwesịrị ekwesị. Cannabidiol dị na 300 mg kwa ụbọchị ejiriwo ọnụ na-echekwa ya ruo ọnwa isii. A na-eji ọnụ dị elu nke 6-1200 mg kwa ụbọchị n'ọnụ n'enweghị nsogbu ruo izu 1500. A na-anabata ọgwụ cannabidiol ọgwụ (Epidiolex) ka a na-eji ọnụ were ọgwụ 4 mg / kg kwa ụbọchị. Cannabidiol sprays nke etinyere n’okpuru ire ejirila na doses nke 25 mg ruo izu 2.5. Otu nwekwara ike itinye mmanụ CBD na nri na ihe ọ drinkụ drinkụ iji kpuchie ụtọ ahụ. Ma maka ndị na-achọ inye aka na ikpere dodgy ma ọ bụ azụ siri ike, a ga-ahọrọ ude.

 

Cannabidiol (CBD) Uru

Cannabidiol (CBD maka nkenke) bụ ihe na-emekarị cannabinoid sitere na osisi cannabis. Ọ bụ otu n'ime ihe karịrị otu narị cannabinoids amata na hemp osisi. Agbanyeghị, n'adịghị ka osisi cannabis zuru ezu, CBD enweghị THC nke bụ maka ọrụ ịtụ nkume / elu nke ọgwụ egwuregwu ahụ na-enye. E wepụtara site na okooko osisi na akụrụ osisi hemp, a na-etinye CBD n'ime mmanụ ma na-ewu ewu na-emeso, na ọbụna gbochie, ọtụtụ nsogbu ahụike na steeti ebe iwu wii wii dị ugbu a. Mmanụ CBD siri ike ma nwekwaa ike karịa ọtụtụ ọgwụ ndị na-abụghị steroidal anti-inflammatory (NSAIDs). Enwere ike ịmịpụta ihe abụọ ahụ ma meziwanye maka ojiji site na mkpụmkpụ ụzọ dị mkpirikpi. Ndị ọrụ nwere ike ịnweta uru ahụike ndị a:

* Ihi ụra na nchegbu

* Ọrịa Neurodegenerative

* Mezie ihe ọdịdọ

*. Nsogbu metụtara ahụike na ọnọdụ uche

* Ogo ụra

* Nchịkwa mgbu

* Ahụike ọkpụkpụ

* Iri Mmadụ Ahụ & Nkwado

* Ọrịa na-adịghị nwayọọ nke ọrịa Alzheimer

* Na-emeso mkpali bowel ọrịa na

* .Helps na-enyere ndị nwere sclerosis otutu nsogbu

 

Cannabidiol (CBD) Akụkụ

Mmetụta dị egwu nke Cannabidiol (CBD) gụnyere ụra, nsogbu nke eriri afọ, ọnụ akọrọ, belata agụụ, ọgbụgbọ, na mmekọrịta na ọgwụ ndị ọzọ.

Cannabidiol (CBD) Ngwa

A na-ejikarị Cannabidiol mee ihe maka ọrịa mberede (epilepsy), Cannabinoid na-ejikarị usoro enzyme P450 cytochrome na-egbochi ọtụtụ enzymes CYP3A4 na CYP2D6. Achọpụtala THC na CBD na-egbochi CYP1A1, 1A2 na 1B1 enzymes n'oge ọmụmụ in vitro. Na mgbakwunye CBD bụ onye nwere ike igbochi CYP2C1P na CYP3A4. Dika otutu ule di iche iche na-aga n'ihu, CBD gosiputara ikike puru iche iji buru ogwugwu nkwado di iche iche. Achọpụtala na ọ nwere antioxidative, mgbochi mkpali, na mmetụta neuroprotective. O gosiputara nkwa na ogwugwo oria akwara dika nchekuta, ihe ngbu ala, trigeminal neuralgia, oria Crohn, oria nke Parkinson tinyere oria mgbaka.

Cannabidiol Summary

Cannabidiol bụ ọnụ cannabinoid nke a na-eji agwọ ọrịa na-arịa ọrịa na-efe efe n'ihi Lennox-Gastaut ma ọ bụ ọrịa Dravet. Cannabidiol na-ejikọta ya na ọgwụ enzyme na-emekarị mgbe a na-agwọ ọrịa karịsịa na usoro ọgwụgwọ dị elu mana ejikọtaghị ya na ọrịa imeju na-ahụ anya na jaundice.

 

Reference

Britch SC, Babalonis S, Walsh SL Canabidiol: nkà mmụta ọgwụ na ọgwụgwọ ọgwụgwọ.Psychopharmacology (Berl). 1 Jenụwarị; 2021 (238): 1-9. ma ọ bụ: 28 / s10.1007-00213-020-05712. PMID: 8.

2. Samanta D.Cannabidiol: Nyochaa nke Ahụike Ahụike na Nchekwa na Epilepsy.Pediatr Neurol. 2019 Jul; 96: 24-29. ma ọ bụ: 10.1016 / j.pediatrneurol. PMID: 31053391.

3. Huestis MA, Solimini R, Pichini S, Pacifici R, Carlier J, Busardò FP.Cannabidiol Mmetụta Ọrịa na Mgbu Ọrịa. Curr Neuropharmacol. 2019; 17 (10): 974-989. ma ọ bụ: 10.2174 / 1570159X17666190603171901.PMID: 31161980.

4. Pisanti S, Malfitano AM wdg Cannabidiol: Ọnọdụ nke nkà na ihe ịma aka ọhụrụ maka ngwa ọgwụgwọ. Pharmacol Ther. Ọrịa. 2017 Jul; 175: 133-150. ma ọ bụ: 10.1016 / j.pharmthera.PMID: 28232276.

5. Burstein S.Cannabidiol (CBD) na analogs ya: nyocha nke mmetụta ha na mbufụt.Bioorg Med Chem. 2015 Epr 1; ​​23 (7): 1377-85. ma ọ bụ: 10.1016 / j.bmc.2015.01.059. PMID: 25703248.

 

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